Extraordinary teen John Smith (Pettyfer) is a fugitive on the run from ruthless enemies sent to destroy him. Changing his identity, moving from town to town with his guardian Henri (Olyphant), John is always the new kid with no ties to his past. In the small Ohio town he now calls home, John encounters unexpected, life-changing events-his first love (Agron), powerful new abilities and a connection to the others who share his incredible destiny.

Lawrence Wetherhold is miserable and misanthropic: he's a widower, a pompous professor at Carnegie Mellon, an indifferent father to a college student and a high-school senior, and the reluctant brother of a ne'er-do-well who's come to town. A seizure and a fall send Lawrence to the emergency room where the physician, a former student of his, ends up going on a date with him. His daughter, Vanessa, lonely and friendless, who's been bonding with his brother, tries to sabotage dad and the doctor's...